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Ginsenoside Rg1 enhances immune response induced by recombinant Toxoplasma gondii SAG1 antigen by Dao-Feng Qu; Hai-Jie Yu; Zhao Liu; De-Fu Zhang; Qian-Jin Zhou; Hong-Li Zhang; Ai-Fang Du is a Immunology and Microbiology article available to read on EtoBox.

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Ginsenoside, the most important component isolated from Panax ginseng, exhibits a variety of biological activities. Particularly, ginsenoside Rg1 is known to have immune-modulating activities such as increase of immune activity of T helper (Th) cells. In the present study, we evaluated the immunomodulatory potentials of the Rg1 at three dose levels on the cellular and humoral immune responses of ICR mice against T. gondii recombinant surface antigen 1 (rSAG1). ICR mice were immunized subcutaneously with 50 g Rg1 alone, 100 g rSAG1 alone or with 100 g rSAG1 dissolved in saline containing ginsenoside Rg1 (10 g, 50 g or 100 g). After immunization, we evaluated the immune response using lymphoproliferative assay, cytokine and antibody measurements, and the survival times of mice challenged lethally. The results showed that the groups immunized with rSAG1 and Rg1 (50 g, 100 g) developed a high level of specific antibody responses against T. gondii rSAG1, a strong lymphoproliferative response, and significant levels of cytokine production, compared with the other groups. After lethal challenge, the mice immunized with the rSAG1 and Rg1 (50 g, 100 g) showed a significantly increased survi

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Author

Dao-Feng Qu; Hai-Jie Yu; Zhao Liu; De-Fu Zhang; Qian-Jin Zhou; Hong-Li Zhang; Ai-Fang Du

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0304-4017)

Published

2011

Language

EN

Field

Immunology and Microbiology (Life Sciences)