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Left Atrial Strain Predicts Exercise Capacity in Heart Failure Independently of Left Ventricular Ejection Fraction by Caterina Maffeis; Andrea Rossi; Lorenzo Cannata; Camilla Zocco; Evgeny Belyavskiy; Aravind Kumar Radhakrishnan; Anna Feuerstein; Daniel Armando Morris; Elisabeth Pieske‐Kraigher; Burkert Pieske; Frank Edelmann; Pier Luigi Temporelli is a Medicine article available to read on EtoBox.
What is Left Atrial Strain Predicts Exercise Capacity in Heart Failure Independently of Left Ventricular Ejection Fraction about?
## Abstract ## Aims We hypothesized that left atrial (LA) remodelling and function are associated with poor exercise capacity as prognostic marker in chronic heart failure (CHF) across a broad range of left ventricular ejection fraction (LVEF). ## Methods and results One hundred seventy‐one patients with CHF were analysed [age 65 ± 11 years, 136 males (80%); 86 heart failure with reduced ejection fraction (HFrEF), 27 heart failure with mid‐range ejection fraction (HFmrEF), 58 heart failure with preserved ejection fraction (HFpEF)]. All patients underwent echocardiography and maximal cardiopulmonary exercise testing and were classified according to a prognostic cut‐off of peak VO~2~ (pVO~2~; 14 mL/kg/min). Seventy‐seven (45%) patients reached pVO~2~ < 14 and 94 (55%) pVO~2~ ≥ 14 mL/kg/min. Between the two groups, there was a considerable difference in both left atrial volume (LAVi, 53 ± 24 vs. 44 ± 18 mL/m^2^, P = 0.005) and function (LA reservoir strain 12 ± 5 vs. 20 ± 10%, P < 0.0001). Receiver‐operating characteristic curves identified LA reservoir strain (area under the curve: 0.73 [0.65–0.80], P < 0.0001) as strong predictor for impaired pVO~2~ among all echocardiographic varia
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- Author
- Caterina Maffeis; Andrea Rossi; Lorenzo Cannata; Camilla Zocco; Evgeny Belyavskiy; Aravind Kumar Radhakrishnan; Anna Feuerstein; Daniel Armando Morris; Elisabeth Pieske‐Kraigher; Burkert Pieske; Frank Edelmann; Pier Luigi Temporelli
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)