Can I read Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis on EtoBox?

Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis by Bertrand N. Mukete; Mark Cassidy; Keith C. Ferdinand; Thierry H. Le Jemtel is a Medicine article available to read on EtoBox.

What is Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis about?

Background Stroke causes approximately 6.7 million deaths worldwide per year and is the second leading cause of death. Pharmacotherapy for hypertension, an independent risk factor for stroke, significantly reduces the incidence of stroke. Although prior meta-analyses demonstrate various antihypertensive classes are superior to placebo in reducing stroke risk, which class is most effective is unclear. Methods We conducted a systematic MEDLINE search including only randomized controlled trials (RCT) of antihypertensive medications published between 1999 and 2014 in adults with stroke as a primary or secondary outcome. Five classes compared against all others were angiotensin-converting enzyme inhibitors (ACEIs), angiotensin receptor blockers (ARBs), b-adrenoceptor antagonists (b-blockers), calcium channel blockers (CCBs), and thiazide or thiazide-like diuretics (T-TLDs). Among 17 RCTs with 31 comparative arms, risk ratio was used to assess effect size, and a fixed-and random-effect model was used to calculate summary effect size, utilizing comprehensive meta-analysis statistical software version 2.0. Results The 251,853 subjects (46 ± 11.4 % female; mean age 67.2 ± 6.8 years), were g

Who reads Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis?

Author

Bertrand N. Mukete; Mark Cassidy; Keith C. Ferdinand; Thierry H. Le Jemtel

Publisher

Springer Science and Business Media LLC

Published

2015

Language

EN

Field

Medicine (Health Sciences)