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Hereditary Spherocytosis Overview by Salim Uddinkhan is a document available to read on EtoBox.
Hereditary spherocytosis is a familial hemolytic disorder caused by mutations that lead to defects in red blood cell membrane proteins. This results in less flexible red blood cells that are damaged as they pass through the spleen, changing their shape from biconcave to spherical. Clinically, it ranges from asymptomatic to fulminant anemia, with complications including aplastic crisis, hemolytic crisis, and gallbladder issues. The classic lab features include mild to moderate anemia, normal to decreased MCV
- Author
- Salim Uddinkhan
- Language
- EN