Can I read Circulating Fibrocytes—Biology and Mechanisms in Wound Healing and Scar Formation on EtoBox?

Circulating Fibrocytes—Biology and Mechanisms in Wound Healing and Scar Formation by Gerrit Grieb; Guy Steffens; Norbert Pallua; Jürgen Bernhagen; Richard Bucala is a book available to read on EtoBox.

What is Circulating Fibrocytes—Biology and Mechanisms in Wound Healing and Scar Formation about?

Fibrocytes were first described in 1994 as fibroblast-like, peripheral blood cells. These bone marrow-derived mesenchymal progenitor cells migrate into regions of tissue injury. They are unique in their expression of hematopoietic and monocyte lineage markers and extracellular matrix proteins. Several studies have focused on the specific role of fibrocytes in the process of wound repair and tissue regeneration. We discuss herein the biology and mechanistic action of fibrocytes in wound healing, scar formation, and maintenance of tissue integrity. Fibrocytes synthesize and secrete different cytokines, chemokines, and growth factors, providing a wound milieu that supports tissue repair. They further promote angiogenesis and contribute to wound closure via pathways involving specific cytokines, leukocyte-specific protein-1, serum amyloid P, and adenosine A(2A) receptors. Fibrocytes are involved in inflammatory fibrotic processes in such diseases as systemic fibrosis, atherosclerosis, asthma, hypertrophic scarring, and keloid formation. Accumulating literature has emphasized the important role of fibrocytes in wound healing and fibrosis. Detailed mechanisms nevertheless remain to be in

Author

Gerrit Grieb; Guy Steffens; Norbert Pallua; Jürgen Bernhagen; Richard Bucala

Publisher

Elsevier

Published

2011

Language

EN