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A novel negative regulator for IL-1 receptor and Toll-like receptor 4 by Foo Y. Liew; Haiying Liu; Damo Xu is a Immunology and Microbiology article available to read on EtoBox.

What is A novel negative regulator for IL-1 receptor and Toll-like receptor 4 about?

The Toll-IL-1 receptor (TIR) superfamily, defined by the presence of an intracellular TIR domain, initiates innate immunity via NF-B activation, leading to production of proinflammatory cytokines. ST2 is a member of the TIR family that does not activate NF-B and has been suggested as an important effector molecule of type 2 T helper cell responses. We have recently demonstrated that the membrane bound form of ST2 (ST2L) negatively regulated IL-1RI and TLR4 but not TLR3 signaling by sequestrating the adaptors MyD88 and Mal. In contrast to wild-type mice, ST2 deficient mice failed to develop endotoxin tolerance. Thus, ST2 suppresses IL-1R and TLR4 signaling via MyD88-and Mal-dependent pathways and modulates innate immunity. The results provide a molecular explanation for the role of ST2 in T H 2 responses since inhibition of TLRs will promote a T H 2 response and also identify ST2 as a key regulator of endotoxin tolerance.

Who reads A novel negative regulator for IL-1 receptor and Toll-like receptor 4?

Author

Foo Y. Liew; Haiying Liu; Damo Xu

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-2478)

Published

2005

Language

EN

Field

Immunology and Microbiology (Life Sciences)