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Polymer-brush Stationary Phases for Open-tubular Capillary Electrochromatography by Matthew D Miller; Gregory L Baker; Merlin L Bruening is a Chemistry article available to read on EtoBox.

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Synthesis of poly(2-hydroxyethyl methacrylate) (PHEMA) brushes from the inside of silica capillaries by surface-initiated atom transfer radical polymerization (ATRP) yields unique stationary phases for open-tubular capillary electrochromatography (OT-CEC). Although PHEMA brushes have only a small effect on the separation of a set of phenols and anilines, derivatization of PHEMA with ethylenediamine (en) allows baseline resolution of several anilines that co-elute from bare silica capillaries. Derivatization of PHEMA with octanoyl chloride (C 8 -PHEMA films) affords even better resolution in the separation of a series of phenols and anilines. Increasing the thickness of C 8 -PHEMA coatings by a factor of 2 enhances resolution for several solute pairs, presumably because of an increase in the effective stationary phase to mobile phase volume ratio. Thus, this work demonstrates that thick polymer brushes provide a tunable stationary phase with a much larger phase ratio than is available from monolayer wall coatings. Through appropriate choice of derivatizing reagents, these polymer brushes should allow separation of a wide range of neutral molecules as well as compounds with similar e

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Author

Matthew D Miller; Gregory L Baker; Merlin L Bruening

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1873-3778)

Published

2004

Language

EN

Field

Chemistry (Physical Sciences)