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Can I read S-Adenosylmethionine revisited: its essential role in the regulation of liver function on EtoBox?
S-Adenosylmethionine revisited: its essential role in the regulation of liver function by Matı́as A Avila; Elena R Garcı́a-Trevijano; Marı́a L Martı́nez-Chantar; M.Ujue Latasa; Isabel Pérez-Mato; L.A Martı́nez-Cruz; Manuel M.Sánchez del Pino; Fernando J Corrales; José M Mato is a Medicine article available to read on EtoBox.
What is S-Adenosylmethionine revisited: its essential role in the regulation of liver function about?
Dietary methionine is mainly metabolized in the liver where it is converted into S-adenosylmethionine (AdoMet), the main biologic methyl donor. This reaction is catalyzed by methionine adenosyltransferase I/III (MAT I/III), the product of MAT1A gene, which is exclusively expressed in this organ. It was first observed that serum methionine levels were elevated in experimental models of liver damage and in liver cirrhosis in human beings. Results of further studies showed that this pathological alteration was due to reduced MAT1A gene expression and MAT I/III enzyme inactivation associated with liver injury. Synthesis of AdoMet is essential to all cells in the organism, but it is in the liver where most of the methylation reactions take place. The central role played by AdoMet in cellular function, together with the observation that AdoMet administration reduces liver damage caused by different agents and improves survival of alcohol-dependent patients with cirrhosis, led us to propose that alterations in methionine metabolism could play a role in the onset of liver disease and not just be a consequence of it. In the present work, we review the recent findings that support this hypot
Who reads S-Adenosylmethionine revisited: its essential role in the regulation of liver function?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Matı́as A Avila; Elena R Garcı́a-Trevijano; Marı́a L Martı́nez-Chantar; M.Ujue Latasa; Isabel Pérez-Mato; L.A Martı́nez-Cruz; Manuel M.Sánchez del Pino; Fernando J Corrales; José M Mato
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0741-8329)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)