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Glycaemic control, disease duration and β-cell function in patients with Type 2 diabetes in a Swedish community. Skaraborg Hypertension and Diabetes Project by C. J. Östgren; U. Lindblad; J. Ranstam; A. Melander; L. Råstam is a Medicine article available to read on EtoBox.

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## Abstract Aims To examine determinants for glycaemic control in primary care patients with Type 2 diabetes. Methods In a community‐based surveillance of primary care patients with Type 2 diabetes, 190 men and 186 women were consecutively identified and examined for cardiovascular risk factors. Insulin resistance and β‐cell function were estimated using homeostasis model assessment (HOMA). Good glycaemic control was defined as HbA~1c~ < 6.5%. Results Following adjustment for age and gender, HbA~1c~≥ 6.5% was associated with duration of diabetes (10.6 vs. 6.4 years, __P__ < 0.001), lower levels of serum insulin (6.3 vs. 8.0 mU/l, __P__ = 0.012), higher serum triglyceride levels (2.0 vs. 1.7 mmol/l, __P__ = 0.002) and impairment of β‐cell function (HOMA index 19.5 vs. 45.8, __P__ < 0.001). The association between HbA~1c~ levels and duration remained with adjustment for age, gender, waist–hip ratio (WHR) and serum triglycerides (odds ratio (OR) for HbA~1c~≥ 6.5% by 5 years diabetes duration = 1.7; 95% confidence interval (CI) 1.4–2.1) but was lost following additional adjustment for β‐cell function (OR for HbA~1c~≥ 6.5%= 1.3; 95% CI 0.96–1.7). In a separate linear regression with β‐c

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Author

C. J. Östgren; U. Lindblad; J. Ranstam; A. Melander; L. Råstam

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0742-3071)

Published

2002

Language

EN

Field

Medicine (Health Sciences)