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Non-invasive in vivo determination of UVA efficacy of sunscreens using diffuse reflectance spectroscopy by R. Gillies; D. Moyal; S. Forestier; N. Kollias is a Medicine article available to read on EtoBox.

What is Non-invasive in vivo determination of UVA efficacy of sunscreens using diffuse reflectance spectroscopy about?

**Background:** Evaluation of sunscreen efficacy is most relevant when measured on the surface it is meant to protect, namely on human skin __in vivo__. Application of any material to the surface of the skin alters its optical properties. Diffuse reflectance spectroscopy (DRS) is a non‐invasive technique to measure changes in the optical properties of the skin decoupled from its biological responses following sunscreen application. **Methods:** This study compared measurements of UVA efficacy of oxybenzone and avobenzone at different concentrations (0–5%) using DRS, human phototest and an __in vitro__ technique. Twenty subjects were enrolled for each product measured by DRS and 10 different subjects were enrolled for each product measured by human phototest. Six areas 5 cm **×** 10 cm were outlined on each subject's back. DRS measurements were performed on four subsites within each area before and 20 min after sunscreen application. UVA efficacy for each concentration of product was calculated from the measured transmission spectrum of a given product convoluted with the spectrum of a Xenon light source adequately filtered to obtain the UVA spectrum from 320 to 400 nm and the eryth

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Author

R. Gillies; D. Moyal; S. Forestier; N. Kollias

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0905-4383)

Published

2003

Language

EN

Field

Medicine (Health Sciences)