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Can I read Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs on EtoBox?
Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs by Helen Y. Chen; Seongkon Kim; Jane Y. Wu; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Johanna Dahllund; Frank DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs about?
A series of 3-alkyl, 3-cycloalkyl, and 3-heteroaryl dihydrobenzoxathiin analogs 1 were prepared and evaluated for estrogen/anti-estrogen activity in both in vitro and in vivo models. In general, the compounds were found to exhibit a high degree of selectivity for ER alpha over ER beta, but were less potent than the original lead compound 1a in the inhibition of estradiol-driven uterine proliferation.
Who reads Estrogen receptor ligands. Part 3: The SAR of dihydrobenzoxathiin SERMs?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Helen Y. Chen; Seongkon Kim; Jane Y. Wu; Elizabeth T. Birzin; Wanda Chan; Yi Tien Yang; Johanna Dahllund; Frank DiNinno; Susan P. Rohrer; James M. Schaeffer; Milton L. Hammond
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2004
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)