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SYNTHESIS AND FUNCTIONALIZATION OF NEW PYRIDO [3,2-f] PYRROLO [1,2-α] [1,4] DIAZEPIN-5-ONES. by Jacques Renault; Fabrice Jourdan; Daniel Laduree; Max Robba is a Chemistry article available to read on EtoBox.

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Starting from the 2-chloro-5-ethyI-6-methylpyridine-3-carbonitrile 1, we achieved the synthesis of new pyridine derivatives £ and 5 whose appropriate treatments furnished new functionalized diazepine heterocycles. Previous diazepines (TIBO, Nevirapine) (1) have shown antiviral activity against HIV-1. We describe here the access to new pyrido [3,2-/] pyrrolo [1,2-a] [1,4] diazepin-5-ones in one or two steps starting from 5-ethyl-6-methyl-2-[2-formyl(pyrrol-l-yl)] pyridin-3-carbonitrile This pathway, different from the one described by Korakas and Varvounis (2) leads to related structures. Structural data of the main compounds 2 to 2 appear in the table 1. Pharmacological investigations about these compounds are in progress.

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Author

Jacques Renault; Fabrice Jourdan; Daniel Laduree; Max Robba

Published

1996

Language

EN

Field

Chemistry (Physical Sciences)