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Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy by Carlen A Yuen; Kourosh Rezania; Deric M Park; Anthony T Reder is a Medicine article available to read on EtoBox.

What is Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy about?

Neurological immune-related adverse events (irAEs) are rare toxicities that occur following immune checkpoint inhibitor therapy. We propose that patients with thymic malignancies and graft-versus-host disease (GVHD) are predisposed to irAEs. We present two asymptomatic patients, one with thymoma and another with GVHD, who developed abnormal brain MRIs after treatment with programmed cell death protein 1 inhibitors. The first patient, with thymic cancer and thymoma, developed pontine enhancing MRI lesions following treatment with pembrolizumab. The second patient, with prior GVHD, developed pachymeningeal enhancement following treatment with nivolumab. IrAEs with abnormal MRI studies, despite asymptomatology, have significant impact on the treatment strategy for these patients.

Who reads Asymptomatic brainstem lesions and pachymeningeal enhancement after anti-PD-1 therapy?

Author

Carlen A Yuen; Kourosh Rezania; Deric M Park; Anthony T Reder

Publisher

Future Medicine Ltd

Published

2020

Language

EN

Field

Medicine (Health Sciences)