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The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47) by Jing An; Shuhui Li; Yufang Zhong; Yipei Wang; Kewen Zhen; Xinyu Zhang; Yangjun Wang; Minghong Wu; Zhiqiang Yu; Guoying Sheng; Jiamo Fu; Yuecheng Huang is a Environmental Science article available to read on EtoBox.
What is The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47) about?
## Abstract Polybrominated diphenyl ethers (PBDE) have been widely applied as flame retardants in plastics, polyurethane foam, paints, and synthetic fabrics. The rising PBDE level in human tissues and environment has led to concern about the health impact of exposure to PBDE. The 2,2′,4,4′‐tetrabromodiphenyl ether (BDE47), the dominant PBDE congener found in the environment and human tissues, has been shown to be an endocrine disruptor. It has also been reported to cause liver and neurodevelopmental toxicity. BDE47 can be metabolized to 6‐OH‐BDE47 and 6‐MeO‐BDE47. So far little has been reported on the cytotoxicity of the metabolites. In the present study, the cytotoxicity of the two metabolites was investigated by exposing human hepatoma cell line HepG2 to different doses of 6‐OH‐BDE47 and 6‐MeO‐BDE47. The cell viability, cell cycle, apoptosis, DNA damage, micronucleus levels, and oxidative stress response were studied. The results indicated that both metabolites could markedly inhibit the proliferation of HepG2 cells with 6‐OH‐BDE47 showing a stronger effect, and significantly increase the micronucleus level and apoptosis rate in a dose‐dependant manner. Moreover, treatment with
Who reads The cytotoxic effects of synthetic 6-hydroxylated and 6-methoxylated polybrominated diphenyl ether 47 (BDE47)?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Jing An; Shuhui Li; Yufang Zhong; Yipei Wang; Kewen Zhen; Xinyu Zhang; Yangjun Wang; Minghong Wu; Zhiqiang Yu; Guoying Sheng; Jiamo Fu; Yuecheng Huang
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1520-4081)
- Published
- 2010
- Language
- EN
- Field
- Environmental Science (Physical Sciences)