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Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue by Carsten Stephan; Monika Jung; Silke Rabenhorst; Ergin Kilic; Klaus Jung is a Medicine article available to read on EtoBox.

What is Urinary miR-183 and miR-205 do not surpass PCA3 in urine as predictive markers for prostate biopsy outcome despite their highly dysregulated expression in prostate cancer tissue about?

## Background: Micrornas (mirnas) have shown to be promising novel biomarkers in various cancers. we aimed to translate the results of an own previous tissue-based mirna profile of prostate carcinoma (pca) with upregulated mir-183 and downregulated mir-205 into a urine-based testing procedure for diagnosis of pca. ## Methods: Urine sediments were prepared from urine samples collected after a standardized digital-rectal examination (dre) of patients undergoing prostate biopsy with psa (prostate-specific antigen) values <20 μg/l in consecutive order. according to the sample-size calculation (α=0.05, power=0.95), 38 patients each with pca and without pca were randomly enrolled in this study. pca3 (prostate cancer associated 3) in urine as food and drug administration-approved assay was determined as reference standard for comparison. the mirnas were measured by rt-qpcr using taqman assays and normalized using different approaches. ## Results: Both mirnas were correlated to the mrna psa concentrations in the sediments indicating a relationship to the released prostate cells after dre. however, they had no discriminating capacity between patients with and without pca. in contrast, pca3

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Author

Carsten Stephan; Monika Jung; Silke Rabenhorst; Ergin Kilic; Klaus Jung

Publisher

Walter de Gruyter GmbH

Published

2015

Language

EN

Field

Medicine (Health Sciences)