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Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway by Fei Chen; Jing-Jing Cui; De-Chun Jiang; Hai-Zheng Wang; Wei Zhuang; Ying-Nan Feng; Xiao-Lan Lin; Sheng-Yan Xi is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Antitumor mechanism of kangliu pill on gliomas in mice through PI3K-Akt signaling pathway about?

Ethnopharmacological relevance Gliomas are common malignant intracranial tumors that have worse prognosis and pose a serious threat to human health. The Kangliu pill (KLP) is an innovative herbal compound from Xuanwu Hospital of Capital Medical University that has been clinically used for the treatment of gliomas for more than 40 years, and is one of the few drugs for primary treatment of this disorder. But the fundamental molecular mechanisms and pathways of KLP are not clear. Aim of the study To investigate the therapeutic mechanism of KLP in the treatment of gliomas. Materials and methods An in situ xenograft model of red fluorescent protein-labeled human glioma cell line (U87-RFP) in BALB/c-nu mouse was established, and the therapeutic effect of KLP on gliomas was assessed by tumor weights and fluorescence areas. A quantitative proteomics approach using tandem mass tags combined with liquid chromatography-tandem mass spectrometry was performed to explore differentially expressed proteins (DEPs) in glioma tissues, and bioinformatics analyses including Gene Ontology analysis, pathway analysis, and network analysis were performed to analyze the proteins involved in the network the

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Author

Fei Chen; Jing-Jing Cui; De-Chun Jiang; Hai-Zheng Wang; Wei Zhuang; Ying-Nan Feng; Xiao-Lan Lin; Sheng-Yan Xi

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Agricultural and Biological Sciences (Life Sciences)