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Can I read Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer on EtoBox?
Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer by Peng, Yilin (author);Zhao, Min (author);Hu, Yinying (author);Guo, Hongyan (author);Zhang, Yanyan (author);Huang, Yanqin (author);Zhao, Lin (author);Chai, Yong (author);Wang, Zhigang (author) is a Immunology and Microbiology article available to read on EtoBox.
What is Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer about?
## Background: Tumor-associated macrophages are considered to be a major contributor affecting the development of tumors. recently, numerous studies have shown that tumor cells were able to educate their microenvironment by delivering a significant amount of exosomes, however, the mechanism that exosomes from pca cells work in macrophage polarization remains obscure. therefore, we sought to determine whether blockade of exosome generation by gw4869, an inhibitor of exosome biogenesis, would impede macrophages from differentiating into m2 cells. ## Results: In this study, we first obtained exosomes from the supernatant media of pca cells cultured with exosome-free serum using the magcaptureTM exosome isolation kit ps, and then investigated their effects on macrophages. our data confirmed that exosomes released by prostate cancer cells can induce macrophages to differentiate into m2 cells. mechanistically speaking, exosomes exert their effects on macrophages through activating the akt and stat3 signaling pathways. importantly, treatment with gw4869 significantly inhibited the release of exosomes from pca cells, and further impaired m2 differentiation of macrophages and their pro-tumo
Who reads Blockade of exosome generation by GW4869 inhibits the education of M2 macrophages in prostate cancer?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Peng, Yilin (author);Zhao, Min (author);Hu, Yinying (author);Guo, Hongyan (author);Zhang, Yanyan (author);Huang, Yanqin (author);Zhao, Lin (author);Chai, Yong (author);Wang, Zhigang (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)