Can I read Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors on EtoBox?

Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors by Mahsa Yarhorhosseini; Shahrzad Javanshir; Ahmad Shahir Sadr; Milad Noori; Navid Dastyafteh; Maryam Esmkhani; Aida Iraji; Mohammad Mahdavi is a Chemistry article available to read on EtoBox.

What is Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors about?

In this study, an environmentally friendly, solvent- and catalyst-free synthesis of 2-anilino nicotinic acids derivatives is reported. This operationally simple and green procedure was applied to a selection of primary aromatic amines giving rise to 23 derivatives of 2-anilino nicotinic acids in a very short reaction time (15–120 min) with good to excellent yield. Next, similarity searches were executed on these derivatives to find the possible biological target. These products were screened for inhibition of COX-1 and COX-2 by molecular docking and dynamic studies. In silico studies revealed that among these derivatives, the structure **10** bearing __meta__-chlorine substitutions could act as COX-1 and COX-2 inhibitors. These results can be used in designing important lead compounds for further development as potential anti-inflammatory drugs. ## Supplementary Information The online version contains supplementary material available at 10.1186/s13065-023-01078-y.

Who reads Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors?

Author

Mahsa Yarhorhosseini; Shahrzad Javanshir; Ahmad Shahir Sadr; Milad Noori; Navid Dastyafteh; Maryam Esmkhani; Aida Iraji; Mohammad Mahdavi

Publisher

Springer Science and Business Media LLC

Published

2023

Field

Chemistry (Physical Sciences)