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Can I read Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection on EtoBox?
Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection by Zou, Min; Liu, Hongmiao; Li, Jingyan; Yao, Xingang; Chen, Yi; Ke, Changwen; Liu, Shuwen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection about?
Zika virus (ZIKV) infection is a global public health problem due to its rapid spread and the possibility of causing microcephaly. Currently, no specific antivirals against ZIKV are available for treatment. In the present study, several flavonoids (galangin, kaempferide, quercetin, myricetin and EGCG) were found to reduce ZIKV induced plaques and viral RNA copies with negligible cytotoxic effects on host cells. In addition, inhibition of ZIKV propagation by flavonoids showed structure-activity relationship. Our results demonstrate flavonoids as inhibitors of ZIKV entry and NS2B-NS3 protease. Hence, these flavonoids could be used as potential bifunctional drugs for treating ZIKV infections.
Who reads Structure-activity relationship of flavonoid bifunctional inhibitors against Zika virus infection?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Zou, Min; Liu, Hongmiao; Li, Jingyan; Yao, Xingang; Chen, Yi; Ke, Changwen; Liu, Shuwen
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0006-2952)
- Published
- 2020
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)