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268 ARE ENDOGENOUS OPIOIDS INVOLVED IN NSAIDS TOLERANCE? by M. Tsagareli; N. Tsiklauri; G. Gurtskaia; I. Nozadze; E. Abzianidze is a Medicine article available to read on EtoBox.

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Poster Sessions / European Journal of Pain 13 (2009) S55-S285 value 1.94 ± 0.74 mg/kg indicating a synergistic interaction. The derived theoretical additive ED 50 value for the gabapentinmetamizole combination (14.22 ± 9.55 mg/kg) was not significantly greater than the observed ED 50 (12.67 ± 5.26 mg/kg), which corresponds to an additive interaction. The derived theoretical additive ED 50 value for the gabapentin-paracetamol combination was 59.95 ± 16.77 mg/kg, while the experimental value of this combination was 127.61±56.98 mg/kg. These data indicate a subadditivity between the gabapentin and paracetamol. Conclusions: Data suggest that low doses of the diclofenacgabapentin combination can interact synergistically and therefore this drug association may represent a therapeutic advantage for the clinical treatment of ipain.

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Author

M. Tsagareli; N. Tsiklauri; G. Gurtskaia; I. Nozadze; E. Abzianidze

Publisher

Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley; FASEB (ISSN 1090-3801)

Published

2009

Language

EN

Field

Medicine (Health Sciences)