Can I read Modern Practical Management of Acute Severe Colitis on EtoBox?
Modern Practical Management of Acute Severe Colitis by Alaa Mohamed Anwar AbdelMeguid; Emma Whitehead; Shaji Sebastian is a Medicine article available to read on EtoBox.
What is Modern Practical Management of Acute Severe Colitis about?
Acute severe ulcerative colitis (ASUC) is one of life-threatening complications that occur in one-fifth of ulcerative colitis (UC) patients with significant morbidity and an estimated mortality rate up to 1%. There are no validated clinical scoring systems for ASUC. Intravenous corticosteroids remain the cornerstone for the management of ASUC patients However, one-third of patients are steroid refractory and require colectomy in the pre-biologic era or salvage therapy in the post-biologic era. The currently available predictors of non-response to steroids and salvages therapy are sub-optimal. Furthermore, there is a need for the development of clear outcome measures for ASUC patients. Although infliximab and cyclosporin are both effective as salvage therapy, they still carry a rate of treatment failure. Hence, there is an unmet need to explore alternative therapeutic options before colectomy particularly in prior infliximab-exposed patients. This may include the introduction of small molecules with rapid onset of action as a salvage or sequential therapy and the use of slow-onset other biological therapy after "bridging" with cyclosporine. In this article, we explore the current be
Who reads Modern Practical Management of Acute Severe Colitis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alaa Mohamed Anwar AbdelMeguid; Emma Whitehead; Shaji Sebastian
- Publisher
- Springer Science and Business Media LLC
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)