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Use of External Beam Radiotherapy Is Associated With Reduced Incidence of Second Primary Head and Neck Cancer: A SEER Database Analysis by Kyle Rusthoven; Changhu Chen; David Raben; Brian Kavanagh is a Medicine article available to read on EtoBox.

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## Purpose: Patients with head and neck cancer have a significant risk of developing a second primary cancer of the head and neck. we hypothesized that treatment with external beam radiotherapy (rt) might reduce this risk, because rt can eradicate occult foci of second head and neck cancer (hnca). ## Methods and materials: The data of patients with surveillance, epidemiology, and end results historic stage a localized squamous cell carcinoma of the oral cavity, larynx, and pharynx were queried using the surveillance, epidemiology, and end results database. for patients treated with or without rt, the incidence of second hnca was determined and compared using the log-rank method. cox proportional hazards analysis was performed for each site, evaluating the influence of covariates on the risk of second hnca. ## Results: Between 1973 and 1997, 27,985 patients were entered with localized hnca. of these patients, 44% had received rt and 56% had not. the 15-year incidence of second hnca was 7.7% with rt vs. 10.5% without rt (hazard ratio 0.71, p <0.0001). the effect of rt was more profound in patients diagnosed between 1988 and 1997 (hazard ratio 0.53, p <0.0001) and those with pharynx p

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Author

Kyle Rusthoven; Changhu Chen; David Raben; Brian Kavanagh

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2008

Language

EN

Field

Medicine (Health Sciences)