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Tranexamic Acid: Current Use in Obstetrics, Major Orthopedic, and Trauma Surgery by Jean Wong; Ronald B. George; Ciara M. Hanley; Chadi Saliba; Doreen A. Yee; Angela Jerath is a Medicine article available to read on EtoBox.

What is Tranexamic Acid: Current Use in Obstetrics, Major Orthopedic, and Trauma Surgery about?

## Purpose: In this continuing professional development module, we review the practical pharmacology of tranexamic acid and its clinical use in trauma, obstetrics, and major orthopedic surgery. ## Principal findings: Tranexamic acid is a synthetic drug that inhibits fibrinolysis. multiple clinical trials in various clinical settings have shown that it can reduce blood loss, transfusion rates, and bleeding-associated mortality. in trauma and obstetrical bleeding, early tranexamic acid administration (< three hours) may have greater clinical benefits. overall, tranexamic acid use appears safe with no significant increase of thromboembolic or seizure events. nevertheless, current evidence has limitations related to wide heterogeneity in dose, route, and timing of drug administration, as well as generalizability of the large-scale trial findings to higher income nations. ## Conclusions: Tranexamic acid is an efficacious and safe pharmacological-based blood conservation technique in the management of clinically significant hemorrhage. all anesthesiologists should have a good understanding of the pharmacotherapeutic properties and perioperative role of tranexamic acid therapy both inside

Who reads Tranexamic Acid: Current Use in Obstetrics, Major Orthopedic, and Trauma Surgery?

Author

Jean Wong; Ronald B. George; Ciara M. Hanley; Chadi Saliba; Doreen A. Yee; Angela Jerath

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)