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What is Somatic Recombination in B Cells about?

Somatic recombination is a process that occurs in B cells during development to generate antibody diversity. It involves the rearrangement of immunoglobulin gene segments through DNA recombination. Susumu Tonegawa discovered that antibody genes can rearrange themselves within a cell. This process is mediated by recombination signal sequences and the RAG1 and RAG2 proteins, which cut DNA to join gene segments together in new combinations, generating coding and signal joints. The resulting antibodies have uni

Author

Noor Ul Naeem

Language

EN