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Effect of Short-term Treatment with Alendronate on Ulnar Bone Adaptation to Cyclic Fatigue Loading in Rats by Jennifer G. Barrett; Susannah J. Sample; Jenna McCarthy; Vicki L. Kalscheur; Peter Muir; Laura Prokuski is a Medicine article available to read on EtoBox.
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## Abstract Targeted remodeling of fatigue‐injured bone involves activation of osteoclastic resorption followed by local bone formation by osteoblasts. We studied the effect of parenteral alendronate (ALN) on bone adaptation to cyclic fatigue. The ulnae of 140 rats were cyclically loaded unilaterally until 40% loss of stiffness developed. We used eight treatment groups: (1) baseline control; (2) vehicle (sterile saline) and (3) alendronate before fatigue, no adaptation (Pre‐VEH, Pre‐ALN, respectively); (4) vehicle and (5) alendronate during adaptation to fatigue (Post‐VEH, Post‐ALN, respectively); (6) vehicle before fatigue and during adaptation (Pre‐VEH/Post‐VEH); (7) alendronate before fatigue and vehicle during adaptation (Pre‐ALN/Post‐VEH); (8) alendronate before fatigue and during adaptation (Pre‐ALN/Post‐ALN). Bones from half the rats/group were tested mechanically; remaining bones were examined histologically. The following variables were quantified: volumetric bone mineral density (vBMD); ultimate force (F~u~); stiffness __(S)__; work‐to‐failure __(U)__; cortical area (Ct.Ar); new woven bone tissue area (Ne.Wo.B.T.Ar); resorption space density (Rs.N/T.Ar). Microcracking was
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- Author
- Jennifer G. Barrett; Susannah J. Sample; Jenna McCarthy; Vicki L. Kalscheur; Peter Muir; Laura Prokuski
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 0736-0266)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)