About this Medicine article
Paediatric-onset Hereditary Spastic Paraplegias: a Retrospective Cohort Study by Schiavoni, Silvia; Spagnoli, Carlotta; Rizzi, Susanna; Salerno, Grazia G; Frattini, Daniele; Pisani, Francesco; Fusco, Carlo is a Medicine article available to read on EtoBox.
## Aim To describe the clinical and neurogenetic spectrum of paediatric‐onset hereditary spastic paraplegias (HSPs) diagnosed in our unit. ## Method We report on 47 patients (30 males, 17 females; mean [SD] age 12y 7mo [6y 2mo], range 4–34y) clinically diagnosed with an HSP at the Child Neurology Unit, IRCCS‐ASMN (Reggio Emilia, Italy) between 1990 and 2018, who were genetically investigated by means of single‐gene direct sequencing and/or next‐generation sequencing technologies (targeted panels, whole‐exome sequencing [WES]). ## Results Complex forms prevailed slightly (n=26), autosomal dominant being the main inheritance pattern (n=11), followed by recessive (n=5) and X‐linked (n=1). A definite genetic diagnosis was achieved in 17 patients. Spastic paraplegia 3A (n=4) was the most frequent cause of autosomal dominant HSP in our cohort, while no genetic variant prevailed in autosomal recessive forms and pathogenic/likely pathogenic variants were disclosed in a wide range of different genes. ## Interpretation We found wide phenotypic and genetic heterogeneity. With increasing accessibility to WES, a higher number of patients receive a diagnosis, allowing detection of variants in ul
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- Author
- Schiavoni, Silvia; Spagnoli, Carlotta; Rizzi, Susanna; Salerno, Grazia G; Frattini, Daniele; Pisani, Francesco; Fusco, Carlo
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Wiley-Blackwell; Wiley (ISSN 0012-1622)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)