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Thiazolidinediones are a class of drugs used to treat type 2 diabetes. They work by activating peroxisome proliferator-activated receptor gamma (PPARγ), which increases insulin sensitivity. Their main mechanism of action is stimulating PPARγ in adipose tissue, muscle and liver. This improves glucose utilization, uptake of fatty acids, and shifts fat distribution. While thiazolidinediones provide benefits like reducing cardiovascular risk factors and helping preserve beta-cell function, they can also cause s

Author

Kumar Sudesh

Language

EN