Can I read Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4 on EtoBox?

Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4 by Shuyao Yu; Yuhui Zhou; Ligang Niu; Yan Qiao; Yu Yan is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4 about?

## Background: The mesenchymal stem cell-derived exosome (mscs-exo) carrying micrornas have been proved to regulate tumor biological activities. clarifying molecular mechanism and identifying predictive micrornas will be of great value in anti-tumor therapy improvement. ## Objective: We aimed to investigate the regulatory role of microrna-342-3p (mir-342-3p) in mscs-exo on breast cancer. ## Methods: Breast cancer tissues and cell lines were used to evaluate mir-342-3p expression in patients with or without lymph node/distal organ metastasis. the impact of mscs-exo expression on tumor cell chemo-resistance and invasion/migration was measured. dual-luciferase reporter gene assay was applied to identify binding site. inhibitor of differentiation 4 (id4) sirna and mir-342-3p inhibitor transfection was conducted to further explore the mir-342-3p/id4 axis on chemo-resistance and metastasis of breast cancer cells. ## Results: Breast cancer cells revealed significantly lower level of mir-342-3p in patients with metastatic diseases. mir-342-3p suppressed invasive and chemo-resistant behavior of breast cancer tumor cells. binding site between mir-342-3p and id4 was proved. id4 could reverse

Who reads Mesenchymal stem cell-derived exosome mir-342-3p inhibits metastasis and chemo-resistance of breast cancer through regulating ID4?

Author

Shuyao Yu; Yuhui Zhou; Ligang Niu; Yan Qiao; Yu Yan

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)