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Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia by Bilecki, Wiktor (author);Maćkowiak, Marzena (author) is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia about?

Schizophrenia pathogenesis remains challenging to define; however, there is strong evidence that the interaction of genetic and environmental factors causes the disorder. This paper focuses on transcriptional abnormalities in the prefrontal cortex (PFC), a key anatomical structure that determines functional outcomes in schizophrenia. This review summarises genetic and epigenetic data from human studies to understand the etiological and clinical heterogeneity of schizophrenia. Gene expression studies using microarray and sequencing technologies reported the aberrant transcription of numerous genes in the PFC in patients with schizophrenia. Altered gene expression in schizophrenia is related to several biological pathways and networks (synaptic function, neurotransmission, signalling, myelination, immune/inflammatory mechanisms, energy production and response to oxidative stress). Studies investigating mechanisms driving these transcriptional abnormalities focused on alternations in transcription factors, gene promoter elements, DNA methylation, posttranslational histone modifications or posttranscriptional regulation of gene expression mediated by non-coding RNAs.

Who reads Gene Expression and Epigenetic Regulation in the Prefrontal Cortex of Schizophrenia?

Author

Bilecki, Wiktor (author);Maćkowiak, Marzena (author)

Publisher

MDPI AG

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)