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Value of Liver Biopsy in the Diagnosis of Drug-induced Liver Injury by Jawad Ahmad; Huiman X. Barnhart; Maurizio Bonacini; Marwan Ghabril; Paul H. Hayashi; Joseph A. Odin; Don C. Rockey; Simona Rossi; Jose Serrano; Hans L. Tillmann; David E. Kleiner is a Medicine article available to read on EtoBox.

What is Value of Liver Biopsy in the Diagnosis of Drug-induced Liver Injury about?

## Background & aims: The utility of liver biopsy in diagnosing or staging idiosyncratic drug-induced liver injury (dili) is unclear. the aim of this study was to determine whether liver histology impacted causality assessment in suspected dili using a novel simulation model. ## Methods: Fifty patients enrolled in the dili network (dilin) who had liver biopsies performed within 60 days of dili onset were randomly selected. all had standard dilin consensus causality scoring using a 5-point scale (1=definite, 2=highly likely, 3=probable, 4=possible, 5=unlikely) based on 6-month post-injury data. three experienced hepatologists independently performed a causality assessment using redacted case records, with the biopsy and selected post-biopsy laboratory data removed. the 3 hepatologists also reviewed the liver histology with a hepatopathologist and then repeated causality assessment for each case. ## Results: Of the 50 cases, there were 42 high causality dili cases (1, 2 or 3) and 8 low causality cases (4 and 5). the hepatologists judged that liver biopsy was indicated in 62% of patients; after histology review, biopsy was judged to have been helpful in 70% of patients. histology revi

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Author

Jawad Ahmad; Huiman X. Barnhart; Maurizio Bonacini; Marwan Ghabril; Paul H. Hayashi; Joseph A. Odin; Don C. Rockey; Simona Rossi; Jose Serrano; Hans L. Tillmann; David E. Kleiner

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)