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Evaluation of polyaza macrocyclic methylene phosphonate chelates of Gd3+ ions as MRI contrast agents by Carlos F. G. C. Geraldes; Rodney D. Brown III; William P. Cacheris; Seymour H. Koenig; A. Dean Sherry; Marga Spiller is a Medicine article available to read on EtoBox.
What is Evaluation of polyaza macrocyclic methylene phosphonate chelates of Gd3+ ions as MRI contrast agents about?
Gd( DTPA)\*-(diethylenetriaminepentaacetic acid) and the polyaza macrocyclic Gd(D0TA)-(1,4,7,10-tetraazacyclododecane-N,N',N",N) are paradigms of general purpose paramagnetic complexes useful for enhancing contrast in magnetic resonance imaging (MRI). It is of both fundamental and practical interest to determine how one might modify the chemical structure of these chelate complexes to improve their utility for MRI in specific circumstances. In the present work, we investigated polyaza methylene phosphonate complexes of Gd3+ ions to compare their NMRD profiles with those of their carboxylate analogs and with Gd( DTPA)'-. We find that the number q of exchangeable water molecules coordinated directly to the Gd3+ ions tends to be smaller in the phosphonates, in principle reducing their utility in MRI. However, these phosphonates have a tendency to oligomerize, and the resulting decrease in rotational mobility of the paramagnetic oligomers increases their relaxivity at higher fields, offsetting the effect of decreases in q . In particular, Gd( (1,5,9-triazacyclododecane-N, N', N",-tris( methylenephosphonic acid)) would be an increasingly effective contrast agent above -10 MHz ifthe olig
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It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Carlos F. G. C. Geraldes; Rodney D. Brown III; William P. Cacheris; Seymour H. Koenig; A. Dean Sherry; Marga Spiller
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 1989
- Language
- EN
- Field
- Medicine (Health Sciences)