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Can I read Cerebral blood volume measurements by rapid contrast infusion and T2*-weighted echo planar MRI on EtoBox?
Cerebral blood volume measurements by rapid contrast infusion and T2*-weighted echo planar MRI by Alina Tudorica; Hai Fang Li; Frank Hospod; Evan Delucia‐Deranja; Wei Huang; Clifford S. Patlak; George C. Newman is a Medicine article available to read on EtoBox.
What is Cerebral blood volume measurements by rapid contrast infusion and T2*-weighted echo planar MRI about?
Cerebral blood volume (CBV) provides information complementary to that of cerebral blood flow in cerebral ischemia, tumors, and other conditions. We have developed an alternative theory and method for measuring CBV based on dynamic imaging by MRI or CT during a short contrast infusion. This method avoids several limitations of traditional approaches that involve waiting for steady state or measuring the area under the curve (AUC) during bolus contrast injection. Anesthetized dogs were studied by T2\*-weighted echo planar imaging during gadolinium-DTPA infusions lasting 30-60 sec. CBV was calculated from the ratio of the signal changes in tissue and artery. Method responsiveness was compared to AUC measurements using the vasodilator acepromazine. The ratio of signal change in tissue to that in artery rapidly approached an asymptotic value even while the amount of contrast in artery continued to increase. Using 30-sec infusions, the mean (+/- SD) of CBV for control animals was 3.6 +/- 0.9 ml blood/100 g tissue in gray matter and 2.3 +/- 0.8 ml blood/100 g tissue in white matter (ratio = 1.6). Acepromazine increased CBV to 5.7 +/- 1.5 ml blood/100 g tissue in gray matter and 3.1 +/- 0
Who reads Cerebral blood volume measurements by rapid contrast infusion and T2*-weighted echo planar MRI?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alina Tudorica; Hai Fang Li; Frank Hospod; Evan Delucia‐Deranja; Wei Huang; Clifford S. Patlak; George C. Newman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)