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Short-term effects of glucagon-like peptide 1 (GLP-1) receptor agonists on fat distribution in patients with type 2 diabetes mellitus: an ultrasonography study by Susanna Morano; Elisabetta Romagnoli; Tiziana Filardi; Luciano Nieddu; Elisabetta Mandosi; Mara Fallarino; Irene Turinese; Mariangela Pia Dagostino; Andrea Lenzi; Vincenzo Carnevale is a Medicine article available to read on EtoBox.
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## Aims: Glucagon-like peptide 1 receptor agonists (glp-1 ra) induce weight loss and reduction in adipose tissue, but the effects of glp-1 ra on the distribution of fat deposits have been poorly investigated. ## Methods: In 25 patients with type 2 diabetes (16 females and 9 males, mean age 63.5 ± 8.8 years), treated with glp-1 ra (exenatide, n. 12; liraglutide, n.13), both before and 3 months after starting treatment, an abdominal ultrasonographic scan, with doppler of renal arteries, and echocardiography were performed. subcutaneous fat width (peri-umbilical and sub-xiphoid), deep fat deposits (pre-aortic, peri-renal, and epicardial), and renal resistive index (ri) were evaluated. ## Results: Glp-1 ra induced highly significant (p < 0.001) decrease in bmi and in fat thickness at all the assessed sites, without differences between exenatide and liraglutide treatment. a slight decrease in ri (p = 0.055) was also found. the percent changes of fat thickness was different between sites (p < 0.025), and the changes in subcutaneous deposits showed no significant correlation (p = 0.064) with those of deep fat deposits. ## Conclusions: A short course of treatment with glp-1 ra, besides wei
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- Author
- Susanna Morano; Elisabetta Romagnoli; Tiziana Filardi; Luciano Nieddu; Elisabetta Mandosi; Mara Fallarino; Irene Turinese; Mariangela Pia Dagostino; Andrea Lenzi; Vincenzo Carnevale
- Publisher
- Springer Science and Business Media LLC
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)