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This article explores the estimation of individual genome-wide autozygosity through runs of homozygosity (ROHs) in European populations, utilizing high-density genome scans. The study compares four populations, including isolated and cosmopolitan groups, and finds that the proportion of the genome in ROHs (Froh) correlates strongly with traditional inbreeding coefficients. This approach provides a more accurate description of genomic autozygosity, which is crucial for identifying recessive disease variants

Author

hangau2023

Language

EN