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Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk by Tianyi Xia; Mulong Du; Huiqin Li; Yuancheng Wang; Junhao Zha; Tong Wu; Shenghong Ju is a Medicine article available to read on EtoBox.
What is Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk about?
Background: A better understanding of the association between liver MRI proton density fat fraction (PDFF) and liver diseases might support the clinical implementation of MRI PDFF. ## Purpose: To quantify the genetically predicted causal effect of liver MRI PDFF on liver disease risk. ## Materials and Methods: This population-based prospective observational study used summary-level data mainly from the UK Biobank and FinnGen. Mendelian randomization analysis was conducted using the inverse variance-weighted method to explore the causal association between genetically predicted liver MRI PDFF and liver disease risk with Bonferroni correction. The individual-level data were downloaded between August and December 2020 from the UK Biobank. Logistic regression analysis was performed to validate the association between liver MRI PDFF polygenic risk score and liver disease risk. Mediation analyses were performed using multivariable mendelian randomization. Results: Summary-level and individual-level data were obtained from 32 858 participants and 378 436 participants (mean age, 57 years ± 8 [SD]; 203 108 female participants), respectively. Genetically predicted high liver MRI PDFF was ass
Who reads Association between Liver MRI Proton Density Fat Fraction and Liver Disease Risk?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Tianyi Xia; Mulong Du; Huiqin Li; Yuancheng Wang; Junhao Zha; Tong Wu; Shenghong Ju
- Publisher
- Radiological Society of North America (RSNA)
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)