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Multiplexed Immunobead-based Profiling of Cytokine Markers for Detection of Nasopharyngeal Carcinoma and Prognosis of Patient Survival by Kai-Ping Chang; Ya-Ting Chang; Chih-Ching Wu; Yu-Ling Liu; Min-Chi Chen; Ngan-Ming Tsang; Cheng-Lung Hsu; Yu-Sun Chang; Jau-Song Yu is a Medicine article available to read on EtoBox.
What is Multiplexed Immunobead-based Profiling of Cytokine Markers for Detection of Nasopharyngeal Carcinoma and Prognosis of Patient Survival about?
## Abstract ## Background The purpose of this study was to examine cytokine profiles of peripheral blood for nasopharyngeal carcinoma (NPC). ## Methods A total of 132 patients with untreated NPC, 169 healthy individuals, and 32 patients with chronic rhinosinusitis (CRS) were enrolled in this study. The plasma levels of 13 cytokines were measured by the multiplexed immunobead‐based method. ## Results The levels of interleukin (IL)‐6, IL‐8, interferon‐inducible protein 10 (IP‐10), tumor necrosis factor (TNF)‐α, vascular endothelial growth factor (VEGF), and macrophage inflammatory protein (MIP)‐3α were significantly elevated in patients with NPC; but the stem cell factor (SCF) levels were significantly lower. The levels of IL‐6, IL‐8, IP‐10, and MIP‐3α were significantly elevated in patients with advanced stages disease and correlated with Epstein–Barr virus (EBV) DNA. A 2‐marker panel consisting of MIP‐3α and SCF increased the screening efficacy of EBV‐specific viral capsid antigen (VCA) IgA or EBV DNA, although the addition of MIP‐3α and SCF to the combined set of currently available markers (EBV VCA IgA and EBV DNA) did not improve the accuracy of the diagnostic panel. The patient
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- Author
- Kai-Ping Chang; Ya-Ting Chang; Chih-Ching Wu; Yu-Ling Liu; Min-Chi Chen; Ngan-Ming Tsang; Cheng-Lung Hsu; Yu-Sun Chang; Jau-Song Yu
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)