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In vitro and in vivo evaluation of carbamazepine-PEG 6000 solid dispersions by Naima Zerrouk; Chantal Chemtob; Philippe Arnaud; Siro Toscani; Jerome Dugue is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

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The present work extended previous physico-chemical investigations on the effects of solid dispersion on the solubility, the dissolution rate and the pharmacokinetic profile of carbamazepine. Solubility studies showed a linear increase in carbamazepine solubility with the increase of PEG 6000 concentration. There is no marked difference between physical mixtures and solid dispersions for the enhancement of carbamazepine solubility by PEG 6000. Less than 60% of pure carbamazepine was dissolved in 90 min. Physical mixtures (carbamazepine phase III) and solid dispersions (carbamazepine phase II) dissolution rates were higher in comparison of the parent drug. The dissolution of carbamazepine phase III was more pronounced than that evoked by the phase II. The dissolution profiles indicated that the percentage of the drug dissolved was dependent on the proportion of PEG 6000. In solid dispersions there was a remarkable enhancement in the dissolution rates of the drug in the vicinity of the eutectic composition as compared with those of corresponding physical mixtures. Hence, the optimum value for the solid dispersion was 80.591.7% of carbamazepine having dissolved within the first 10 min

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Author

Naima Zerrouk; Chantal Chemtob; Philippe Arnaud; Siro Toscani; Jerome Dugue

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

2001

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)