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Nicardipine use in cerebrovascular disease: A review of controlled clinical studies by Francesco Amenta; Alessia Lanari; Fiorenzo Mignini; Giorgio Silvestrelli; Enea Traini; Daniele Tomassoni is a Medicine article available to read on EtoBox.

What is Nicardipine use in cerebrovascular disease: A review of controlled clinical studies about?

Nicardipine is a dihydropyridine-type Ca 2+ channel blocker (CCB) with strong antihypertensive activity and with a peculiar cerebrovascular profile. This paper has reviewed the main controlled clinical studies on nicardipine in pathologies associated with cerebrovascular impairment. Subarachnoid haemorrhage (SAH) is managed with CCBs to prevent vasospasm and improve clinical outcomes. Nimodipine is the CCB licensed for this indication. Former studies did not demonstrate an advantage of nicardipine versus nimodipine in SAH. A more recent approach administering the drug intra-arterially or using implants of nicardipine prolongedrelease showed a decreased incidence of vasospasm, delayed ischemic deficits and improved clinical outcome after severe SAH. Nicardipine is recommended for elevated blood pressure after acute ischemic stroke or intracerebral haemorrhage and is effective in prevention of stroke. More recent investigations were focused on the treatment of cognitive deterioration of vascular origin. In this setting nicardipine has been investigated in more than 6000 patients, with improvement of cognitive deterioration in more than 60% of patients treated. The anti-hypertensive a

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Author

Francesco Amenta; Alessia Lanari; Fiorenzo Mignini; Giorgio Silvestrelli; Enea Traini; Daniele Tomassoni

Publisher

Elsevier BV

Published

2009

Language

EN

Field

Medicine (Health Sciences)