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Can I read Developmental profiles in young children with Prader–Labhart–Willi syndrome: Effects of weight and therapy with growth hormone or coenzyme Q~10~ on EtoBox?
Developmental profiles in young children with Prader–Labhart–Willi syndrome: Effects of weight and therapy with growth hormone or coenzyme Q~10~ by Urs Eiholzer; Udo Meinhardt; Valentin Rousson; Nelica Petrovic; Michael Schlumpf; Dagmar l'Allemand is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Developmental profiles in young children with Prader–Labhart–Willi syndrome: Effects of weight and therapy with growth hormone or coenzyme Q~10~ about?
## Abstract Muscle hypotonia and failure to thrive are key symptoms of Prader–Willi syndrome (PWS) allowing diagnosis during infancy already. Improved general care as well as Coenzyme Q~10~ (CoQ~10~) and growth hormone (GH) are administered to improve PWS children's outcome. This study aims to investigate psychomotor development of young PWS children in relation to body weight and body composition at baseline as well as to the effects of GH or CoQ~10~ therapy. Twenty‐six young children (age 1.0 ± 0.1 years, mean ± SEM) with PWS genetically proven at age 0.1 ± 0.1 years (17 deletions, 8 maternal disomy) were divided into three groups: Group 1 on GH therapy (started in 1994–1996, 6 mg/kg/week) tolerating low body weight ( 50th centile. Anthropometry, body composition and Griffith's developmental scores (DQs) were assessed before therapy and after 12 months. DQs were not related to infants' weight, lean mass or genetic background. DQs improved significantly with chronological age and were best in the most recently diagnosed group. Improved psychomotor development, mainly due to progress in locomotor development, did not differ between GH and CoQ~10~ treated groups. In conclusion, whil
Who reads Developmental profiles in young children with Prader–Labhart–Willi syndrome: Effects of weight and therapy with growth hormone or coenzyme Q~10~?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Urs Eiholzer; Udo Meinhardt; Valentin Rousson; Nelica Petrovic; Michael Schlumpf; Dagmar l'Allemand
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1552-4825)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)