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This study investigates the effects of 26 rhodopsin (RHO) mutations associated with autosomal-dominant retinitis pigmentosa (RP) using transgenic Xenopus laevis models. The findings reveal that most mutations lead to retinal degeneration (RD) without significantly altering RHO localization or glycosylation, except for specific mutations like P23H and S176F which exhibit distinct mislocalization. Additionally, light exposure appears to influence RD in multiple class B1 RHO mutants, suggesting environmental f

Author

shenwc66

Language

EN